Negative social ties

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Institutes of Health

Humans1

Associations

Multimorbidity

upin humans1

1 study

Negative social ties are associated with multimorbidity in humans.
“negative social ties are associated with accelerated biological aging and a broad range of health outcomes, including inflammation and multimorbidity”
Humans
Negative social ties as emerging risk factors for accelerated aging, inflammation, and multimorbidity
Proceedings of the National Academy of Sciences of the United States of America18 Feb 2026

Latest

1 in 12 months

PNAS18 Feb