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N(ω)-hydroxy-nor-l-arginine

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: Agencia Estatal de Investigación and 8 more
  • Humans1

Outcomes

2

Endothelial dysfunction

downin mice1

1 study

  1. N(ω)-hydroxy-nor-l-arginine decreases endothelial dysfunction in mice.

    “Endothelial dysfunction was reverted by nor-NOHA, an arginase inhibitor.”

    Animalsin old WT miceaortamales

    Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II

    International journal of molecular sciencesFeb 11, 2023

More on Endothelial dysfunction

Acetylcholine-induced vasodilation

upin human cells1

1 study

  1. N(ω)-hydroxy-nor-l-arginine improves acetylcholine-induced vasodilation in human cells.

    “N(ω)-hydroxy-nor-l-arginine restored the acetylcholine-induced vasodilation in young and, to a lesser extent, in old obese subjects.”

    Cellsobesity; effect abolished by addition of L-NAMEsmall artery

    Aging Modulates the Influence of Arginase on Endothelial Dysfunction in Obesity

    Arteriosclerosis, thrombosis, and vascular biologyOct 1, 2018

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