N-heneicosane

Intervention

1 paper4 findings

  • 1 lab
  • Animals1

Outcomes

4

Humoral and cellular immune responses

upin mice1

1 study
  1. N-heneicosane induces humoral and cellular immune responses in mice.

    “strong humoral and cellular responses were also generated following a single immunization in 18-month-old mice”

    Animalssolid emulsionsingle immunization

    Single vaccine dose produced lasting immune responses in mice

    International journal of pharmaceutics: XOct 6, 2026

Cellular immune responses

upin mice1

1 study
  1. N-heneicosane induces cellular immune responses in mice (IFN-γ and IL-2 response observed after 180 days).

    “a single subcutaneous immunization with antigen-loaded n-heneicosane emulsions elicited robust and long-lasting antigen-specific antibody responses and cellular immune responses in mice.”

    Animalsantigen-loaded solid emulsionsplenocytessingle immunization180 days post-immunization

    Single vaccine dose produced lasting immune responses in mice

    International journal of pharmaceutics: XOct 6, 2026

Antigen-specific antibody responses

upin mice1

1 study
  1. N-heneicosane induces antigen-specific antibody responses in mice (Sustained for 165 days after a single immunization).

    “a single subcutaneous immunization with antigen-loaded n-heneicosane emulsions elicited robust and long-lasting antigen-specific antibody responses and cellular immune responses in mice.”

    Animalsantigen-loaded solid emulsionsingle immunization165 days

    Single vaccine dose produced lasting immune responses in mice

    International journal of pharmaceutics: XOct 6, 2026

Pro-inflammatory cytokine production

upin mouse cells1

1 study
  1. N-heneicosane increases pro-inflammatory cytokine production in mouse cells.

    “The slow-release formulation demonstrated prolonged antigen release and promoted pro-inflammatory cytokine production without inducing significant cytotoxicity.”

    Cellsslow-release solid emulsiondendritic cells

    Single vaccine dose produced lasting immune responses in mice

    International journal of pharmaceutics: XOct 6, 2026

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International Journal of Pharmaceutics

Single vaccine dose produced lasting immune responses in mice

Antibody responses persisted for 165 days after one dose, while immune cells from the spleen showed responses at 180 days.Antibody responses persisted for 165 days after one dose, while immune cells from the spleen showed responses at 180 days.