My-hsc depletion
My-hsc depletion has been studied in 1 paper since 2024: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Mar 27, 2024: “Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity”.
1 paper studies it3 findingsUpdated
- 1 lab in 1 country
- Funders: National Cancer Institute and 7 more
- Animals1
What did studies of My-hsc depletion find?
3Studies of My-hsc depletion measured 3 outcomes; the most studied are markers of immune decline (1 study), adaptive immune response (1) and common lymphocyte progenitors (1).
Markers of immune decline
downin mice1
1 study
Markers of immune decline
downin mice1
My-hsc depletion decreases markers of immune decline in mice.
“while decreasing age-related markers of immune decline”
Animalsin aged mice
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity
Nature
Adaptive immune response
upin mice1
1 study
Adaptive immune response
upin mice1
My-hsc depletion improves adaptive immune response in mice.
“Depletion of my-HSCs in aged mice improves primary and secondary adaptive immune responses to viral infection.”
Animalsin aged mice
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity
Nature
Common lymphocyte progenitors
upin mice1
1 study
Common lymphocyte progenitors
upin mice1
My-hsc depletion increases common lymphocyte progenitors in mice.
“antibody-mediated depletion of my-HSCs in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells”
Animalsin aged mice
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity
Nature