Multidomain lifestyle programmes

Intervention4 papers4 findings

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

2 independent labs in 2 countries

Funders: Alzheimer Society Research Program and 2 more

Human trial1

Outcomes

Memory

upin humans1

1 study

Multidomain lifestyle programmes improve memory in humans.
Reviewliving without dementia
Exercise-only interventions and exercise-based multidomain lifestyle interventions to promote cognitive function in older adults without dementia: a systematic review and meta-analysis · British journal of sports medicine · 21 Sep 2026

Vitality

upin humans1

1 study

Multidomain lifestyle programmes improve vitality in humans.
Reviewcommunity-dwelling older adults with decline in at least one IC domain
WHO-ICOPE-Aligned Multidomain Interventions for Intrinsic Capacity in Community-Dwelling Older Adults: A Systematic Review of Randomised Controlled Trials · Journal of applied gerontology : the official journal of the Southern Gerontological Society · 15 Sep 2026

Locomotion

upin humans1

1 study

Multidomain lifestyle programmes improve locomotion in humans.
Reviewcommunity-dwelling older adults with decline in at least one IC domain
WHO-ICOPE-Aligned Multidomain Interventions for Intrinsic Capacity in Community-Dwelling Older Adults: A Systematic Review of Randomised Controlled Trials · Journal of applied gerontology : the official journal of the Southern Gerontological Society · 15 Sep 2026