Mitorubin

1. Mitorubin has no effect on lifespan in mice.

   “Mitorubin did not shorten lifespan in aged mice”

   Animalsin aged mice

   Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

   npj aging·20 Mar 2026

2. Mitorubin extends lifespan in mice.

   “significantly extended lifespan in high-fat diet-fed mice”

   Animalsin high-fat diet-fed mice

   Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

   npj aging·20 Mar 2026

1. Mitorubin decreases myocardial hypertrophy in mice.

   “suppressed myocardial hypertrophy, and alleviated pulmonary congestion.”

   Animalsin mouse model of age-related cardiac dysfunction

   Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

   npj aging·20 Mar 2026

More on Myocardial hypertrophy

1. Mitorubin improves cardiac function in mice.

   “oral administration of Mitorubin restored mitochondrial function, improved cardiac performance, suppressed myocardial hypertrophy, and alleviated pulmonary congestion.”

   Animalsin mouse model of age-related cardiac dysfunction

   Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

   npj aging·20 Mar 2026