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Microglial replacement

Exposure

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

1

Young-like myeloid cell transcriptional state

upin mice1

1 study

  1. Microglial replacement induces young-like myeloid cell transcriptional state in mice.

    “the trajectory analysis showed a significant transition from aged to young state in Rep-MG compared to only a modest youthful shift in Rep-Mo/MΦ”

    Animalsintracerebral hemorrhage; pronounced shift in microglia and modest shift in monocytes/macrophagesbrain microglia, monocytes and macrophages

    Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement

    Frontiers in immunology24 Jul 2025

Associations

2

Immune response

mixedin mice1

1 study

  1. Microglial replacement is associated with immune response in mice.

    “Both MG and Mo/MΦ experience modification of immune responses after microglial repopulation, with more prominent changes in MG.”

    Animalsintracerebral hemorrhage; changes more prominent in microgliabrain microglia, monocytes and macrophages

    Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement

    Frontiers in immunology24 Jul 2025

More on Immune response

Myeloid cell composition and molecular signatures

mixedin mice1

1 study

  1. Microglial replacement is associated with myeloid cell composition and molecular signatures in mice.

    “We observed similarities but strong divergence in the composition and molecular change features of myeloid cells between the replacement (Rep) and control (Con) groups”

    Animalsintracerebral hemorrhage; replacement versus controlbrain

    Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement

    Frontiers in immunology24 Jul 2025

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