Methylmercury
- 1 lab in 1 country
- Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 3 more
- Animals1
Outcomes
2DNA damage response
upin rats1
1 study
DNA damage response
upin rats1
Methylmercury induces DNA damage response in rats.
“Toxicological effects observed in F2 included chronic DNA damage, bone marrow toxicity, altered microglial content, reduced neuronal signal, and diminished male longevity.”
Animalsancestral F0 exposure during gestation and breastfeeding
Chemosphere23 Jan 2024
Lifespan
downin rats1
1 study
Lifespan
downin rats1
Methylmercury shortens lifespan in rats.
“Toxicological effects observed in F2 included chronic DNA damage, bone marrow toxicity, altered microglial content, reduced neuronal signal, and diminished male longevity.”
Animalsancestral F0 exposure during gestation and breastfeedingmales
Chemosphere23 Jan 2024
Associations
1Histone modification and chromatin remodelling
mixedin rats1
1 study
Histone modification and chromatin remodelling
mixedin rats1
Methylmercury is associated with histone modification and chromatin remodelling in rats.
“Additionally, the study demonstrated that MeHg and VitA affected histone methylation and caused consistent effects in F2.”
Animalsancestral F0 exposure during gestation and breastfeeding
Chemosphere23 Jan 2024
Funding
1 grant since 2021Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Latest
1 in 12 monthsBiogerontology
Synergistic effects of 3-O-methylquercetin and polyphenols on longevity, healthspan, and neuroprotection via FOXO/Nrf2
Experiments in wormsInterventions
Ecotoxicology and Environmental Safety
Exposure to four typical heavy metals induced telomere shortening of peripheral blood mononuclear cells in relevant with declined urinary aMT6s in rats
Experiments in animalsMechanisms