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Media ph buffering

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 2 more
  • Cells1

Outcomes

2

polyQ aggregation into inclusion bodies

upin yeast cells1

1 study

  1. Media ph buffering increases polyQ aggregation into inclusion bodies in yeast cells.

    “Buffering media pH promotes both polyQ aggregation into IBs and promotes longevity.”

    Cellscells expressing pathogenic polyQ expansion proteins

    Adjusting extracellular pH restores proteostasis and extends lifespan in a yeast model of polyglutamine toxicity

    bioRxiv (Cold Spring Harbor Laboratory)8 Sep 2025Preprint

Chronological lifespan

upin yeast cells1

1 study

  1. Media ph buffering extends chronological lifespan in yeast cells.

    “Buffering media pH promotes both polyQ aggregation into IBs and promotes longevity.”

    Cellscells expressing pathogenic polyQ expansion proteins

    Adjusting extracellular pH restores proteostasis and extends lifespan in a yeast model of polyglutamine toxicity

    bioRxiv (Cold Spring Harbor Laboratory)8 Sep 2025Preprint

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