Meclizine

Meclizine shortens lifespan in worms.

“both compounds exert a toxic effect at higher doses, significantly shortening lifespan.”

Model organismsat higher doseshigher doses

Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans · microPublication biology · 14 Sep 2026

Meclizine has no effect on lifespan in worms.

“Our results indicate that cinnarizine and meclizine have no effect on C. elegans lifespan at lower doses”

Model organismsat lower doseslower doses

Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans · microPublication biology · 14 Sep 2026