Maternal separation

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: Canadian Institutes of Health Research

Animals1

Outcomes

FosB-positive cells

downin rats1

1 study

Maternal separation decreases FosB-positive cells in rats.
“In the PVN, the number of FosB expressing cells decreased with age; this effect was greater in NMS females.”
Animals3 h/day from postnatal days 3 to 12paraventricular nucleus of the hypothalamusfemales
Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension
Experimental physiology31 Jan 2026

Latest

1 in 12 months

Experimental Physiology1 Feb

Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension

Experiments in ratsMechanisms

Paper

Maternal separation

Outcomes

Latest

Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension

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