Maternal longevity

Exposure

1 paper2 findings

  • 1 lab in 1 country
  • Funders: HORIZON EUROPE Framework Programme and 1 more
  • Humans1

Outcomes

1

Age of onset

downin humans1

1 study
  1. Maternal longevity decreases age of onset in humans (β = -0.081, 95%CI = [-0.148, -0.013]).

    “higher maternal age of death was associated with an earlier disease onset (β = -0.081, 95%CI = [-0.148, -0.013], P = 0.019).”

    HumansIn AD patientsn = 893

    Maternal Longevity is Associated With Reduced Risk but an Earlier Onset of Alzheimer's Disease in Offspring

    Journal of geriatric psychiatry and neurology16 Feb 2026

Associations

1

Alzheimer's disease

downin humans1OR 0.989

1 study
  1. Maternal longevity lowers the risk of Alzheimer's disease in humans (OR: 0.989, 95%CI = [0.982, 0.997]).

    “Maternal longevity was inversely associated with AD risk (OR: 0.989, 95%CI = [0.982, 0.997], P = 0.005).”

    Humansadjusting for confoundersn = 3,069

    Maternal Longevity is Associated With Reduced Risk but an Earlier Onset of Alzheimer's Disease in Offspring

    Journal of geriatric psychiatry and neurology16 Feb 2026

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