Macronutrient intake

Macronutrient intake has been studied in 11 papers since 2018: 7 observational studies in people, 1 in animals, 2 reviews; 3 in the past year. The newest paper, Jun 5, 2026: “Eating Behavior and Dietary Components Associated with Waist Circumference in Japanese Adults: A Cross-Sectional Study”.

Intervention

11 papers study it6 findingsUpdated

See all 11 papers on macronutrient intake

At a glance

The findings reach people, from one lab or study. 4 independent labs in 4 countries.

“corroborating earlier FGF21 and FTO findings”
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortiumMolecular psychiatry2018doi:10.1038/s41380-018-0079-4

None of its findings points the other way.

Worms or flies and humans: a single group. Cells and mice: nothing yet.
  • 4 independent labs in 4 countries
  • Funders: British Heart Foundation and others
  • 2 of 5 findings with company ties
  • Humans7
  • Model organisms1
  • In silico1

What did studies of macronutrient intake find?

1

Studies of macronutrient intake measured one outcome, lifespan extension.

Lifespan extension

mediatesin reviews1

1 study
  1. Macronutrient intake mediates lifespan extension (dietary restriction).

    “recent evidence suggests that macronutrient intake underpins the effect of DR”

    Reviewdietary restriction

    Lifespan Extension Via Dietary Restriction: Time to Reconsider the Evolutionary Mechanisms?

    BioEssays : news and reviews in molecular, cellular and developmental biology

What is macronutrient intake linked with?

5

Studies link macronutrient intake with 5 measures, among them random blood glucose, sarcopenic obesity and fecundity.

Random blood glucose

upin humans1

1 study
  1. Macronutrient intake is associated with random blood glucose in humans.

    “There was a significant positive association between macronutrient intake and blood glucose levels in older adults at PSLU Mandalika”

    Humans

    Association of Macronutrient Intake and Physical Activity with Random Blood Glucose Levels in Older Adults at PSLU Mandalika

    Jurnal Pendidikan Sains Geologi dan Geofisika (GeoScienceEd Journal)

More on Random blood glucose

Sarcopenic obesity

downin humans1

1 study
  1. Macronutrient intake is associated with sarcopenic obesity in humans (inverse association with both sarcopenic obesity and sarcopenic overweight).

    “an inverse association was found between SOW and SO and physical activity and macronutrient intake”

    Humansinverse association with both sarcopenic obesity and sarcopenic overweightn = 119,494

    Prevalence of sarcopenic obesity and sarcopenic overweight in the general population: The lifelines cohort study

    Clinical nutrition (Edinburgh, Scotland)

More on Sarcopenic obesity

Fecundity

mixedin T. oceanicus1

1 study
  1. Macronutrient intake is associated with fecundity in T. oceanicus (jointly with micronutrient intake).

    “early life fecundity (cumulative fecundity at day 21) and lifetime fecundity were dependent on both macronutrient and micronutrient intakes”

    Model organismsjointly with micronutrient intakefemales

    Sex differences in nutrient intake can reduce the potential for sexual conflict over fitness maximization by female and male crickets

    Journal of evolutionary biology

FTO

mixedin humans1

1 study
  1. FTO is associated with macronutrient intake in humans (combined meta-analysis of 123,659 European descent participants).

    “corroborating earlier FGF21 and FTO findings”

    Humanscombined meta-analysis of 123,659 European descent participantsn = 123,659

    Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

    Molecular psychiatry

More on FTO

FGF21

mixedin humans1

1 study
  1. FGF21 is associated with macronutrient intake in humans (combined meta-analysis of 123,659 European descent participants).

    “corroborating earlier FGF21 and FTO findings”

    Humanscombined meta-analysis of 123,659 European descent participantsn = 123,659

    Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

    Molecular psychiatry

More on FGF21

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 2Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 03 papers in 12 months

See all 11 papers on macronutrient intake