Ls-c

Light- and enzyme-gated prodrugs target senescent cells

Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung…Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung cancer patient-derived organoids.