Lower body negative pressure
Lower body negative pressure has been studied in 4 papers since 2019: 3 observational studies in people, 1 review. The newest paper, Aug 1, 2024: “Compensatory reserve index during central hypovolemia and volume loading in healthy young and older hyperthermic adults: A pilot study”.
“LBNP increased circulating EPO in young women (p = 0.023) but not in young men or older individuals.”
None of its findings points the other way.
- 3 independent labs in 4 countries
- Funders: National Heart, Lung, and Blood Institute and 5 more
- Humans3
What did studies of Lower body negative pressure find?
4Studies of Lower body negative pressure measured 4 outcomes; the most studied are carotid baroreflex heart rate gain (1 study), copeptin (1) and EPO (1).
Carotid baroreflex heart rate gain
downin humans1
1 study
Carotid baroreflex heart rate gain
downin humans1
Lower body negative pressure is linked with lower carotid baroreflex heart rate gain in humans (P = 0.003).
“it depressed CBR-HR gains in both groups (LBNP factor P = 0.003).”
Humansfemales
Experimental biology and medicine (Maywood, N.J.)
Copeptin
upin humans1
1 study
Copeptin
upin humans1
Lower body negative pressure increases copeptin in humans (acute hemodynamic regulation).
“Copeptin was increased in all individuals with LBNP but was exclusively associated with EPO in men (r = 0.39, p = 0.013).”
Human trialacute hemodynamic regulation
Acute regulation of erythropoietin via lower body negative pressure: Influence of sex and age
Scandinavian journal of medicine & science in sports
EPO
upin humans1
1 study
EPO
upin humans1
Lower body negative pressure increases EPO in humans (acute hemodynamic regulation).
“LBNP increased circulating EPO in young women (p = 0.023) but not in young men or older individuals.”
Human trialacute hemodynamic regulationfemales
Acute regulation of erythropoietin via lower body negative pressure: Influence of sex and age
Scandinavian journal of medicine & science in sports
Carotid compliance coefficient
downin humans1
1 study
Carotid compliance coefficient
downin humans1
Lower body negative pressure is linked with lower carotid compliance coefficient in young but not middle-age/older adults (young: Δ-0.04±0.01; MA/O: Δ0.001±0.008 mm2/mmHg).
“whereas carotid compliance coefficient during lower body negative pressure was significantly reduced in young but not MA/O (young: Δ-0.04±0.01 versus MA/O: Δ0.001±0.008 mm2·mm Hg−1, P<0.01)”
Humansin young but not middle-age/older adultsgraded levels
Hypertension (Dallas, Tex. : 1979)