Lisinopril

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Humans1
Model organisms1

Outcomes

Oxygen consumption rate

downin flies1

1 study

Lisinopril decreases oxygen consumption rate in flies.
“Lisinopril prevented the age-related rise in metabolic rate in B line females”
Model organismsin B line femalesfemales
Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin-Converting Enzyme Inhibitor Lisinopril
Aging cell15 Jan 2026

Healthspan

upin reviews1

1 study

Lisinopril improves healthspan.
“ACE inhibitors, such as the commonly prescribed vasodilator lisinopril, have been shown to exert beneficial effects on healthspan.”
Reviewreview of evidence
Angiotensin-Converting Enzyme Inhibitors and Metabolic Aging: A Drosophila Perspective
Biomolecules28 Sep 2025

Associations

Metabolic rate

mixedin flies1

1 study

Lisinopril is associated with metabolic rate in flies.
“Recent studies in Drosophila reveal sex-, age-, and genetic background-specific effects of lisinopril on metabolic rates and aging-related organismal phenotypes.”
Reviewsex-, age-, and genetic background-specific
Angiotensin-Converting Enzyme Inhibitors and Metabolic Aging: A Drosophila Perspective
Biomolecules28 Sep 2025