Very low energy ketogenic therapy + liraglutide

Intervention

1 paper4 findings

  • 1 lab in 1 country
  • Human trial1

Outcomes

4

Nausea

upin humans1

1 study
  1. Very low energy ketogenic therapy + liraglutide increases nausea in humans (p<0.001).

    “Despite the metabolic benefits, the VLEKT +Lira group reported a higher incidence of adverse effects, including nausea (p<0.001), heartburn (0.004), reflux (p=0.009)”

    Humansfour-month

    SUN-675 Very Low Energy Ketogenic Therapy In Combination With Liraglutide As A Synergic Strategy For The Treatment Of Obesity: A Real-world Clinical Evaluation

    ENDO 2025 abstract22 Oct 2025

Ketone

upin humans1

1 study
  1. Very low energy ketogenic therapy + liraglutide increases ketone in humans.

    “Ketone levels were higher in the combination group, suggesting improved adherence to the dietary regimen.”

    Humansfour-month

    SUN-675 Very Low Energy Ketogenic Therapy In Combination With Liraglutide As A Synergic Strategy For The Treatment Of Obesity: A Real-world Clinical Evaluation

    ENDO 2025 abstract22 Oct 2025

More on Ketone

Insulin resistance

downin humans1

1 study
  1. Very low energy ketogenic therapy + liraglutide decreases insulin resistance in humans (p<0.001).

    “and a more pronounced reduction in insulin resistance (p<0.001).”

    Humansfour-month

    SUN-675 Very Low Energy Ketogenic Therapy In Combination With Liraglutide As A Synergic Strategy For The Treatment Of Obesity: A Real-world Clinical Evaluation

    ENDO 2025 abstract22 Oct 2025

More on Insulin resistance

Body weight

downin humans1

1 study
  1. Very low energy ketogenic therapy + liraglutide decreases body weight in humans (-20.4% vs -14.7%, p = 0.013).

    “However, the VLEKT +Lira group experienced greater weight loss (-20.4% vs -14.7%, p = 0.013)”

    Humansfour-month

    SUN-675 Very Low Energy Ketogenic Therapy In Combination With Liraglutide As A Synergic Strategy For The Treatment Of Obesity: A Real-world Clinical Evaluation

    ENDO 2025 abstract22 Oct 2025

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