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Liquid-liquid interface

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Japan Society for the Promotion of Science
  • Cells1

Outcomes

2

Phenotypic heterogeneity

downin human cells1

1 study

  1. Liquid-liquid interface decreases phenotypic heterogeneity in human cells.

    “These findings highlight the importance of using a liquid-liquid interface to suppress spontaneous phenotypic heterogeneity by promoting uniform cell distribution.”

    Cellsreplacing Y27632 on laminin-332-coated liquid-liquid interface

    Cultivation at a liquid-liquid interface prevents phenotypic heterogeneity of human induced pluripotent stem-derived retinal pigment epithelial cells

    New biotechnology14 Oct 2025

Tight junction formation, FZ

upin human cells1

1 study

  1. Liquid-liquid interface increases tight junction formation, FZ in human cells (FZ = 0.97, HLN = 0.95).

    “Quantitative analysis revealed that the levels of tight junction formation, FZ, and the homogeneity index, i.e., the degree of uniform cell distribution, HLN, were consistent between the central and peripheral regions”

    Cellswith forskolin on laminin-332-coated liquid-liquid interface

    Cultivation at a liquid-liquid interface prevents phenotypic heterogeneity of human induced pluripotent stem-derived retinal pigment epithelial cells

    New biotechnology14 Oct 2025

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