Levothyroxine

1. Levothyroxine has no effect on bone mineral density in humans.

   Humansmales

   Levothyroxine use and bone loss: Longitudinal analysis among euthyroid men and women from the Baltimore Longitudinal Study of Aging · Bone · 23 Sep 2026

2. Levothyroxine decreases bone mineral density in humans (-0.010 g/cm2/year (95% CI -0.015 to -0.006)).

   Humansfemales

   Levothyroxine use and bone loss: Longitudinal analysis among euthyroid men and women from the Baltimore Longitudinal Study of Aging · Bone · 23 Sep 2026

Bone mineral density →

1. Levothyroxine improves lipids in humans.

   Reviewin overt hypothyroidism

   Cardiovascular Risk Prediction in Hypothyroidism: What Current Models Capture and Miss—A Narrative Review · Preprints.org · 16 Sep 2026 · Preprint

Lipids →