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Lasmiditan

Intervention

1 paper4 findings

PubChem 11610526

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Foundation for the National Institutes of Health and 6 more
  • Animals1

Outcomes

4

Mitochondrial biogenesis (PGC-1α)

upin mice1

1 study

  1. Lasmiditan increases mitochondrial biogenesis (PGC-1α) in mice.

    “These behavioral changes were associated with enhanced MB and mitochondrial function”

    Animalsin Thy1-aSyn mice

    Lasmiditan ameliorates cortico-hippocampal pathology and improves cognition in aging parkinsonian mice

    Experimental neurology12 Oct 2025

More on Mitochondrial biogenesis (PGC-1α)

Alpha-synuclein aggregation

downin mice1

1 study

  1. Lasmiditan decreases alpha-synuclein aggregation in mice.

    “reduced alpha-synuclein aggregation particularly in cortico-hippocampal regions”

    Animalsin Thy1-aSyn micecortico-hippocampal regions

    Lasmiditan ameliorates cortico-hippocampal pathology and improves cognition in aging parkinsonian mice

    Experimental neurology12 Oct 2025

More on Alpha-synuclein aggregation

Anxiety-like behavior

downin mice1

1 study

  1. Lasmiditan decreases anxiety-like behavior in mice.

    “Anxiety-like behavior was also improved”

    Animalsin Thy1-aSyn mice1 mg/kg, every other day

    Lasmiditan ameliorates cortico-hippocampal pathology and improves cognition in aging parkinsonian mice

    Experimental neurology12 Oct 2025

Cognitive function

upin mice1

1 study

  1. Lasmiditan improves cognitive function in mice.

    “reversed cognitive deficits in young (4-5.5 months old) Thy1-aSyn mice (1 mg/kg, every other day)”

    Animalsin Thy1-aSyn mice1 mg/kg, every other day

    Lasmiditan ameliorates cortico-hippocampal pathology and improves cognition in aging parkinsonian mice

    Experimental neurology12 Oct 2025

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