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Vitamin D + l-theanine

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: King Saud University
  • Animals1

Outcomes

4

Oxidative stress and ROS signalling

downin mice1

1 study

  1. Vitamin D + l-theanine decreases oxidative stress and ROS signalling in mice (P < 0.0001).

    “significant reductions in MDA and enhancements in endogenous antioxidant enzymes (SOD, catalase, P < 0.0001).”

    Animalsin an aged murine model of unpredictable chronic mild stress2 mg/kg + 500 IU/kg

    Nutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement

    Experimental gerontology1 Sep 2025

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Depressive symptoms

downin mice1

1 study

  1. Vitamin D + l-theanine decreases depressive symptoms in mice (P < 0.05).

    “Co-treatment with L-theanine (2 mg/kg) and vitamin D (500 IU/kg) robustly reversed these deficits, surpassing the efficacy of monotherapy (P < 0.05).”

    Animalsin an aged murine model of unpredictable chronic mild stress2 mg/kg + 500 IU/kg

    Nutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement

    Experimental gerontology1 Sep 2025

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Dopamine

upin mice1

1 study

  1. Vitamin D + l-theanine increases dopamine in mice (Δcurrent = 1.99 μA vs. UCMS 0.66 μA).

    “Amperometric brain homogenate analysis revealed dopaminergic recovery (Δcurrent = 1.99 μA vs. UCMS 0.66 μA)”

    Animalsin an aged murine model of unpredictable chronic mild stress2 mg/kg + 500 IU/kg

    Nutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement

    Experimental gerontology1 Sep 2025

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Alpha oscillations

upin mice1

1 study

  1. Vitamin D + l-theanine increases alpha oscillations in mice (2.33-fold increase vs. UCMS, P < 0.0001).

    “Vit D + L-thea restored alpha oscillations (8-13 Hz power: 2.33-fold increase vs. UCMS, P < 0.0001)”

    Animalsin an aged murine model of unpredictable chronic mild stress2 mg/kg + 500 IU/kg

    Nutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement

    Experimental gerontology1 Sep 2025

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