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KU-60019 + Y-27632

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Basic Research Laboratory and 3 more
  • Cells1

Outcomes

2

Cell cycle regulation

upin human cells1

1 study

  1. KU-60019 + Y-27632 activates cell cycle regulation in human cells.

    “promotes the G2/M transition via FOXM1 activation, leading to accumulation of cells undergoing the G1/S transition via E2F1 activation”

    Cellsco-inhibition of ATM and ROCK

    Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1

    Communications biologyJul 14, 2022

More on Cell cycle regulation

Cell proliferation

upin human cells1

1 study

  1. KU-60019 + Y-27632 increases cell proliferation in human cells.

    “co-inhibition of ATM and ROCK by KU-60019 and Y-27632, respectively, synergistically increases the proliferation of human diploid fibroblasts undergoing replicative senescence”

    Cellsin human diploid fibroblasts undergoing replicative senescence

    Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1

    Communications biologyJul 14, 2022

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