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Joint replacement

Joint replacement has been studied in 5 papers since 2017: 4 observational studies in people, 1 review. The newest paper, Oct 1, 2025: “Risk Factors for Perioperative Myocardial Infarction/Injury and Mortality Following Surgical Treatment of Proximal Femur Fractures: A Cohort Study”.

Exposure

5 papers study it3 findingsUpdated

See all 5

“However, the joint replacement allowed for earlier ambulation after the operation and rapid recovery of the hip joint function.”
Cementless Bipolar Hemiarthroplasty Compared With Proximal Femoral Nail Anti-rotation of Unstable Intertrochanteric Fractures in Senile Patients With Osteoporosis: a Retrospective StudyResearch Square2021doi:10.21203/rs.3.rs-955577/v1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Deutsches Zentrum fur Luft - und Raumfahrt and others
  • Humans4

What did studies of Joint replacement find?

3

Studies of Joint replacement measured 3 outcomes; the most studied are frailty (1 study), weight-bearing time out of bed (1) and hip joint function (1).

Frailty

downin humans1

1 study

  1. Joint replacement is linked with lower frailty in humans (pre-frail hip and knee osteoarthritis) (1.56 ± 0.50 to 0.53 ± 0.73, p < 0.001).

    “In the pre-frail group, the PFP score decreased from 1.56 ± 0.50 (median 2) preoperatively to 0.53 ± 0.73 (median 0) 3 months after surgery (p < 0.001).”

    Humanspre-frail hip and knee osteoarthritis3 monthsn = 50

    The impact of primary total hip and knee replacement on frailty: an observational prospective analysis

    BMC musculoskeletal disorders

Weight-bearing time out of bed

downin humans1

1 study

  1. Joint replacement decreases weight-bearing time out of bed in humans (osteoporotic unstable intertrochanteric fractures) (P<0.05).

    “joint replacement allowed for earlier ambulation after the operation”

    Human trialosteoporotic unstable intertrochanteric fracturesn = 52

    Cementless Bipolar Hemiarthroplasty Compared With Proximal Femoral Nail Anti-rotation of Unstable Intertrochanteric Fractures in Senile Patients With Osteoporosis: a Retrospective Study

    Research SquarePreprint

Hip joint function

upin humans1

1 study

  1. Joint replacement improves hip joint function in humans (osteoporotic unstable intertrochanteric fractures) (P<0.05).

    “However, the joint replacement allowed for earlier ambulation after the operation and rapid recovery of the hip joint function.”

    Human trialosteoporotic unstable intertrochanteric fractureswithin 6 months of operationn = 52

    Cementless Bipolar Hemiarthroplasty Compared With Proximal Femoral Nail Anti-rotation of Unstable Intertrochanteric Fractures in Senile Patients With Osteoporosis: a Retrospective Study

    Research SquarePreprint

Funding

9 grants since 2018

National Institute of Arthritis and Musculoskeletal and Skin Diseases$1.2MNational Institute of Child Health and Human Development$1.1MAgency for Healthcare Research and Quality$735K

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