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JM03

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 3 more
  • Model organisms1

Outcomes

2

Polyglutamine Q35 aggregation

downin worms1

1 study

  1. JM03 decreases polyglutamine Q35 aggregation in worms.

    “the inhibition of OSM-9 by JM03 reduces the aggregation of Q35 in C. elegans via upregulating the genes associated with proteostasis.”

    Model organismsvia upregulating the genes associated with proteostasis

    Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9

    eLifeMay 5, 2022

More on Polyglutamine Q35 aggregation

Lifespan

upin worms1

1 study

  1. JM03 extends lifespan in worms.

    “crotamiton derivative JM03 was obtained and showed better activity in terms of lifespan-extension and stress resistance than crotamiton.”

    Model organismsvia inhibiting OSM-9

    Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9

    eLifeMay 5, 2022

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