Polyglutamine Q35 aggregation

1 paper studies it1 finding

Model organisms1

Interventions

1

JM03

downin worms1

1 study

JM03 decreases polyglutamine Q35 aggregation in worms.
“the inhibition of OSM-9 by JM03 reduces the aggregation of Q35 in C. elegans via upregulating the genes associated with proteostasis.”
Model organismsvia upregulating the genes associated with proteostasis
Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9
eLifeMay 5, 2022

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eLifeMay 6

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9

Experiments in wormsInterventions