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Ivermectin

Intervention

2 papers5 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Consejo Nacional de Ciencia y Tecnología and 1 more
  • Animals1
  • Model organisms1

Outcomes

5

Immunosenescence

no changein E. intermedius1

1 study

  1. Ivermectin has no effect on immunosenescence in E. intermedius.

    “ivermectin effects on these immune mechanisms were constant across ages, revealing no immunosenescence caused by ivermectin.”

    Model organisms

    Immunosuppression and senescence in dung beetles exposed to ivermectin

    bioRxiv (Cold Spring Harbor Laboratory)17 Sep 2025Preprint

Prophenoloxidase activity

no changein E. intermedius1

1 study

  1. Ivermectin has no effect on prophenoloxidase activity in E. intermedius.

    “female proPO was not affected by ivermectin or age.”

    Model organismsfemales

    Immunosuppression and senescence in dung beetles exposed to ivermectin

    bioRxiv (Cold Spring Harbor Laboratory)17 Sep 2025Preprint

More on Prophenoloxidase activity

Phenoloxidase and prophenoloxidase activity

downin E. intermedius1

1 study

  1. Ivermectin decreases phenoloxidase and prophenoloxidase activity in E. intermedius.

    “Whereas males suffered a reduction in PO and proPO with ivermectin and age, female proPO was not affected by ivermectin or age.”

    Model organismsmales

    Immunosuppression and senescence in dung beetles exposed to ivermectin

    bioRxiv (Cold Spring Harbor Laboratory)17 Sep 2025Preprint

More on Phenoloxidase and prophenoloxidase activity

Cell death

downin mouse cells1

1 study

  1. Ivermectin protects against cell death in mouse cells.

    “Complete protection was found after preincubation of the motor neurons with ivermectin or Cibacron Blue 3G-A.”

    Cellskainate-induced excitotoxicity in cultured motor neurons

    Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

    Neurobiology of disease12 Oct 2006

Lifespan

upin mice1

1 study

  1. Ivermectin extends lifespan in mice (almost 10%).

    “treated SOD1(G93A)-mice, a transgenic animal model for familial ALS, with ivermectin. This resulted in an extension of the life span of these mice with almost 10%.”

    Animalsin SOD1(G93A) transgenic mice

    Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

    Neurobiology of disease12 Oct 2006

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