Itraconazole + lacosamide

1 paper5 findings

PubChem 55283 PubChem 219078 ChEBI 6076 ChEBI 135939

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Department of Biotechnology, Ministry of Science and Technology, Government of India and 1 more

Model organisms1

Outcomes

RNA splicing

upin human cells1

1 study

Itraconazole + lacosamide improves RNA splicing in human cells.
“suppressed FMR1polyG aggregation and corrected CGG repeat splicing defects”
Cellsin (CGG)99 transfected HEK293T and COS-7 cells
Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome
ACS chemical neuroscience22 Sep 2026

More on RNA splicing

Lifespan

upin flies1

1 study

Itraconazole + lacosamide extends lifespan in flies.
“extended the lifespan of model flies, with a fourfold reduction in the effective ITZ dose”
Model organismsin model flies
Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome
ACS chemical neuroscience22 Sep 2026

Locomotor performance

upin flies1

1 study

Itraconazole + lacosamide improves locomotor performance in flies.
“Notably, this combination also improved locomotor performance and extended the lifespan of model flies”
Model organismsin model flies
Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome
ACS chemical neuroscience22 Sep 2026

Oxidative stress and ROS signalling

downin flies1

1 study

Itraconazole + lacosamide decreases oxidative stress and ROS signalling in flies.
“attenuated oxidative stress and cell death in an in vivoDrosophila model of FXTAS”
Model organismsin an in vivo Drosophila model of FXTAS
Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome
ACS chemical neuroscience22 Sep 2026

More on Oxidative stress and ROS signalling

FMR1polyG aggregation

downin flies1

1 study

Itraconazole + lacosamide decreases FMR1polyG aggregation in flies.
“The ITZ+LCM combination significantly reduced FMR1polyG aggregation and attenuated oxidative stress and cell death in an in vivoDrosophila model of FXTAS.”
Model organismsin an in vivo Drosophila model of FXTAS
Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome
ACS chemical neuroscience22 Sep 2026

Latest

1 in 12 months

ACS Chemical Neuroscience23 Sep

Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome

Experiments in fliesInterventions

Paper

Itraconazole + lacosamide

Outcomes

Latest

Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome

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