FMR1polyG aggregation

1. Itraconazole + lacosamide decreases FMR1polyG aggregation in flies.

   “The ITZ+LCM combination significantly reduced FMR1polyG aggregation and attenuated oxidative stress and cell death in an in vivoDrosophila model of FXTAS.”

   Model organismsin an in vivo Drosophila model of FXTAS

   Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome

   ACS chemical neuroscience·22 Sep 2026

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