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Intestinal alkaline phosphatase

Intervention

2 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 2 more
  • Animals1

Outcomes

6

Lifespan

upin mice2

2 studies

  1. Intestinal alkaline phosphatase extends lifespan in mice.

    “In normal mice, exogenous supplemental IAP reverses age-induced barrier dysfunction, improves aging-associated metabolic dysfunction, prevents microbiome dysbiosis (imbalance), and extends life-span.”

    Reviewin normal mice

    Supplementation with Brush Border Enzyme Alkaline Phosphatase Slows Aging

    Rejuvenation research1 Apr 2020

  2. Intestinal alkaline phosphatase extends lifespan in mice.

    “resulted in less frailty, and extended lifespan”

    Animalsaging

    Intestinal alkaline phosphatase targets the gut barrier to prevent aging

    JCI insight26 Mar 2020

Physical function

upin flies1

1 study

  1. Intestinal alkaline phosphatase improves physical function in flies.

    “increased dietary IAP increases aging-diminished physical performance in flies.”

    Reviewin flies

    Supplementation with Brush Border Enzyme Alkaline Phosphatase Slows Aging

    Rejuvenation research1 Apr 2020

Microbiome composition

downin mice1

1 study

  1. Intestinal alkaline phosphatase prevents microbiome composition in mice.

    “In normal mice, exogenous supplemental IAP reverses age-induced barrier dysfunction, improves aging-associated metabolic dysfunction, prevents microbiome dysbiosis (imbalance), and extends life-span.”

    Reviewin normal mice

    Supplementation with Brush Border Enzyme Alkaline Phosphatase Slows Aging

    Rejuvenation research1 Apr 2020

More on Microbiome composition

Frailty

downin mice1

1 study

  1. Intestinal alkaline phosphatase decreases frailty in mice.

    “resulted in less frailty, and extended lifespan”

    Animalsaging

    Intestinal alkaline phosphatase targets the gut barrier to prevent aging

    JCI insight26 Mar 2020

systemic inflammation

downin mice1

1 study

  1. Intestinal alkaline phosphatase decreases systemic inflammation in mice.

    “Oral IAP supplementation significantly decreased age-related gut permeability and gut-derived systemic inflammation”

    Animalsaging

    Intestinal alkaline phosphatase targets the gut barrier to prevent aging

    JCI insight26 Mar 2020

Gut permeability

downin mice1

1 study

  1. Intestinal alkaline phosphatase decreases gut permeability in mice.

    “Oral IAP supplementation significantly decreased age-related gut permeability and gut-derived systemic inflammation”

    Animalsaging

    Intestinal alkaline phosphatase targets the gut barrier to prevent aging

    JCI insight26 Mar 2020

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