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Intermittent protein restriction

Intervention

3 papers12 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 3 countries
  • Funders: National Natural Science Foundation of China and 4 more
  • Animals2
  • Model organisms1

Outcomes

11

Hyperglycemia

downin mice1downin rats1

2 studies

  1. Intermittent protein restriction decreases hyperglycemia in rats.

    “Administration of IPR significantly reduced hyperglycemia and decreased glucose production in the liver.”

    Animalsin Zucker diabetic fatty rats

    Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells

    The Journal of nutritional biochemistryJan 18, 2023

  2. Intermittent protein restriction decreases hyperglycemia in mice.

    “IPR drastically reduced hyperglycemia in both streptozotocin-treated and leptin receptor-deficient db/db mouse models.”

    Animalsin streptozotocin-treated and db/db mice

    Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice

    Science bulletinDec 31, 2021

Stem cell activity

downin flies1

1 study

  1. Intermittent protein restriction decreases stem cell activity in flies.

    “Furthermore, this diet reduced the chemotherapy-induced stem cell activity associated with tumor recurrence.”

    Model organismsintestinal cancer model after chemotherapy

    Recurrent Phases of Strict Protein Limitation Inhibit Tumor Growth and Restore Lifespan in A Drosophila Intestinal Cancer Model

    Aging and diseaseNov 14, 2023

Lifespan

upin flies1

1 study

  1. Intermittent protein restriction extends lifespan in flies.

    “This nutritional regime reduced tumor mass, restored gut functionality, and rescued the lifespan of oncogene-expressing flies to the levels observed in healthy flies”

    Model organismsintestinal cancer model (human RAF gain-of-function)

    Recurrent Phases of Strict Protein Limitation Inhibit Tumor Growth and Restore Lifespan in A Drosophila Intestinal Cancer Model

    Aging and diseaseNov 14, 2023

Tumor mass

downin flies1

1 study

  1. Intermittent protein restriction decreases tumor mass in flies.

    “This nutritional regime reduced tumor mass, restored gut functionality, and rescued the lifespan of oncogene-expressing flies to the levels observed in healthy flies”

    Model organismsintestinal cancer model (human RAF gain-of-function)

    Recurrent Phases of Strict Protein Limitation Inhibit Tumor Growth and Restore Lifespan in A Drosophila Intestinal Cancer Model

    Aging and diseaseNov 14, 2023

β cell dedifferentiation

downin rats1

1 study

  1. Intermittent protein restriction decreases β cell dedifferentiation in rats.

    “IPR was able to reverse the diabetes-associated β cell dedifferentiation.”

    Animalsin Zucker diabetic fatty ratspancreatic islets

    Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells

    The Journal of nutritional biochemistryJan 18, 2023

β cell proliferation

upin rats1

1 study

  1. Intermittent protein restriction increases β cell proliferation in rats.

    “elevated the number and the proliferation activity of β cells.”

    Animalsin Zucker diabetic fatty ratspancreatic islets

    Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells

    The Journal of nutritional biochemistryJan 18, 2023

Islet damage

downin rats1

1 study

  1. Intermittent protein restriction protects against islet damage in rats.

    “IPR protected pancreatic islets from diabetes-mediated damages”

    Animalsin Zucker diabetic fatty ratspancreatic islets

    Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells

    The Journal of nutritional biochemistryJan 18, 2023

Glucose production

downin rats1

1 study

  1. Intermittent protein restriction decreases glucose production in rats.

    “decreased glucose production in the liver.”

    Animalsin Zucker diabetic fatty ratsliver

    Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells

    The Journal of nutritional biochemistryJan 18, 2023

More on Glucose production

Liver damage

downin mice1

1 study

  1. Intermittent protein restriction decreases liver damage in mice.

    “IPR caused less lipid accumulation and damage in the liver than that caused by continuous protein restriction in streptozotocin-treated mice.”

    Animalsin streptozotocin-treated miceliver

    Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice

    Science bulletinDec 31, 2021

Glucose production

downin mice1

1 study

  1. Intermittent protein restriction decreases glucose production in mice.

    “IPR reduced glucose production in the liver and elevated insulin signaling in the skeletal muscle.”

    Animalsliver

    Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice

    Science bulletinDec 31, 2021

All 11

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