Intermittent caloric restriction

1. Intermittent caloric restriction decreases body fat percentage in humans (-6.0 ± 1.9%).

   “body fat percentage (p < 0.001), which decreased by 6.7 ± 2.1% in the CCR group and 6.0 ± 1.9% in the DRF group”

   Human trialobesityintermittent caloric restriction with structured diet refeeds and planned diet breaks12 weeksfemalesn = 30

   The Effects of Continuous vs. Intermittent Caloric Restriction on Fat Loss: A Randomized Controlled Trial

   Nutrients·5 Jun 2026

1. Intermittent caloric restriction inhibits angiogenesis in mice.

   “downregulating extracellular matrix organization and positive regulation of angiogenesis”

   AnimalsMMTV-TGF-ɑ miceintermittentmammary fat padfemales

   Distinct transcriptomic effects of intermittent and chronic caloric restriction in mammary fat pad of a breast cancer mouse model

   PloS one·23 Sep 2025

More on Angiogenesis

1. Intermittent caloric restriction decreases extracellular matrix remodelling in mice.

   “downregulating extracellular matrix organization and positive regulation of angiogenesis”

   AnimalsMMTV-TGF-ɑ miceintermittentmammary fat padfemales

   Distinct transcriptomic effects of intermittent and chronic caloric restriction in mammary fat pad of a breast cancer mouse model

   PloS one·23 Sep 2025

More on Extracellular matrix remodelling

1. Intermittent caloric restriction improves neuroendocrine signaling in mice.

   “ICR appeared to mitigate this age-related decline in neuroendocrine signaling by upregulating genes involved in neurotransmitter support”

   AnimalsMMTV-TGF-ɑ miceintermittentmammary fat padfemales

   Distinct transcriptomic effects of intermittent and chronic caloric restriction in mammary fat pad of a breast cancer mouse model

   PloS one·23 Sep 2025