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Interleukin-1

Interleukin-1 has been studied in 5 papers since 1992: 1 trial in people, 3 in animals, 1 review. Its furthest trials in people are at phase 1. The newest paper, Nov 16, 2022: “Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling”.

InterventionPhase 1

5 papers study it3 findingsUpdated

MeSH

See all 5 papers on Interleukin-1

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country; 1 trial, none about aging, 1 with no results posted.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

About aging: the drug’s trials about aging. The total counts its trials for every use.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

  • 1 lab in 1 country
  • 1 trial, none about aging, 1 with no results posted
  • Funders: National Science Foundation and 2 more
  • Human trial1
  • Animals3

What did studies of Interleukin-1 find?

3

Studies of Interleukin-1 measured 3 outcomes: Tet2+/- clonal expansion, lymphoid potential and thymic epithelial cell proliferation.

Tet2+/- clonal expansion

upin mice1

1 study

  1. Interleukin-1 increases Tet2+/- clonal expansion in mice carrying CHIP.

    “Administration of IL-1 to mice carrying CHIP led to an IL-1 receptor 1 (IL-1R1)-dependent expansion of Tet2+/- hematopoietic stem and progenitor cells (HSPCs) and mature blood cells.”

    Animalsin mice carrying CHIP

    Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling

    Blood

More on Tet2+/- clonal expansion

Lymphoid potential

downin reviews1

1 study

  1. Interleukin-1 inhibits lymphoid potential.

    “interleukin-1 inhibits Ly-HSC lymphoid potential”

    Reviewlymphoid-biased hematopoietic stem cell

    Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny

    Stem cell reports

Thymic epithelial cell proliferation

upin reviews1

1 study

  1. Interleukin-1 increases thymic epithelial cell proliferation.

    “Thymic epithelial cells respond to IL-1 with proliferation and secretion of IL6 and GM-CSF.”

    Reviewthymic epithelial cell

    Thymic endocrinology

    International journal of immunopharmacology

Has Interleukin-1 been tested in people?

0 of 1 about aging

Yes: 1 trial in people have been published, and 1 trial is registered.

In trials

Trial sponsors

Funding

1 grant since 2021

UKRI | Medical Research Council

Contains public sector information licensed under the Open Government Licence v3.0.

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