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IGF-1 + IGFBP3

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases and 1 more
  • Animals1

Outcomes

1

Bone formation

upin rats1

1 study

  1. IGF-1 + IGFBP3 increases bone formation in rats.

    “injection of IGF-1 plus IGF binding protein 3 (IGFBP3), but not injection of IGF-1 alone, increased the concentration of IGF-1 in the bone matrix and stimulated new bone formation in aged rats.”

    Animals

    Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

    Nature medicine1 Jul 2012

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