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Hydralazine

Intervention

5 papers2 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 5 more
  • Animals5

Mouse lifespan

NIA ITP

Outcomes

2

Cyst growth

downin mice1

1 study

  1. Hydralazine decreases cyst growth in mice.

    “knockout of Dnmt1 and targeting DNMT1 with hydralazine, a safe demethylating agent, delays cyst growth in Pkd1 mutant kidneys”

    Animalsin Pkd1 mutant kidneys

    DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease

    Kidney international21 May 2024

Lifespan

upin mice1

1 study

  1. Hydralazine extends lifespan in mice.

    “targeting DNMT1 with hydralazine, a safe demethylating agent, delays cyst growth in Pkd1 mutant kidneys and extends life span of Pkd1 conditional knockout mice.”

    Animalsin Pkd1 conditional knockout mice

    DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease

    Kidney international21 May 2024

Funding

1 grant since 2022

Japan Society for the Promotion of ScienceJP¥4.2m

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