Human umbilical cord mesenchymal stem cells
Intervention1 paper4 findings
- Animals1
Outcomes
4Sex hormone signalling (oestrogen, androgen)
upin mice1Very low certainty
1 study
Sex hormone signalling (oestrogen, androgen)
upin mice1Very low certainty
Human umbilical cord mesenchymal stem cells activate sex hormone signalling (oestrogen, androgen) in mice.
Animalsin cyclophosphamide-induced premature ovarian failureovaryfemales
Human umbilical cord mesenchymal stem cells enhance folliculogenesis and fertility in premature ovarian failure mice via regulating steroid synthesis · Stem cells (Dayton, Ohio) · 17 Sep 2026
Atretic follicle ratio
downin mice1−50%Very low certainty
1 study
Atretic follicle ratio
downin mice1−50%Very low certainty
Human umbilical cord mesenchymal stem cells decrease atretic follicle ratio in mice (-50%).
Animalsin cyclophosphamide-induced premature ovarian failureovaryfemales
Human umbilical cord mesenchymal stem cells enhance folliculogenesis and fertility in premature ovarian failure mice via regulating steroid synthesis · Stem cells (Dayton, Ohio) · 17 Sep 2026
Fertility
upin mice1Very low certainty
1 study
Fertility
upin mice1Very low certainty
Human umbilical cord mesenchymal stem cells improve fertility in mice (30% to 60%).
Animalsin cyclophosphamide-induced premature ovarian failurefemales
Human umbilical cord mesenchymal stem cells enhance folliculogenesis and fertility in premature ovarian failure mice via regulating steroid synthesis · Stem cells (Dayton, Ohio) · 17 Sep 2026
Follicle counts
upin mice1Very low certainty
1 study
Follicle counts
upin mice1Very low certainty
Human umbilical cord mesenchymal stem cells increase follicle counts in mice (8-fold).
Animalsin cyclophosphamide-induced premature ovarian failureovaryfemales
Human umbilical cord mesenchymal stem cells enhance folliculogenesis and fertility in premature ovarian failure mice via regulating steroid synthesis · Stem cells (Dayton, Ohio) · 17 Sep 2026