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HSF1 activators

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

3

Cognitive function

upin mice1

1 study

  1. HSF1 activators improve cognitive function in mice.

    “pharmacologically enhancing HSF1 improved age-related BAT senescence, metabolic decline, and cognitive dysfunction.”

    Animalsage-related decline

    Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

    eLife3 Oct 2025Preprint

Metabolic homeostasis

upin mice1

1 study

  1. HSF1 activators improve metabolic homeostasis in mice.

    “pharmacologically enhancing HSF1 improved age-related BAT senescence, metabolic decline, and cognitive dysfunction.”

    Animalsage-related decline

    Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

    eLife3 Oct 2025Preprint

Cellular senescence

downin mice1

1 study

  1. HSF1 activators decrease cellular senescence in mice.

    “pharmacologically enhancing HSF1 improved age-related BAT senescence, metabolic decline, and cognitive dysfunction.”

    Animalsage-related declinebrown adipose tissue

    Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

    eLife3 Oct 2025Preprint

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