High-intensity cycling

High-intensity cycling has been studied in 2 papers since 2018: 2 trials in people; 1 in the past year. The newest paper, Nov 1, 2025: “Exercise intensity affects circulating C1q/TNF-related proteins and follistatin-like 1 concentrations”.

Intervention

2 papers study it3 findingsUpdated

“In the HIE trial, significant increases in the circulating concentrations of CTRP3, CTRP9, and FSTL1 were observed after exercise compared to before exercise”
Exercise intensity affects circulating C1q/TNF-related proteins and follistatin-like 1 concentrationsClinical physiology and functional imaging2025doi:10.1111/cpf.70036

None of its findings points the other way.

  • 1 lab
  • Human trial2

What did studies of High-intensity cycling find?

3

Studies of High-intensity cycling measured 3 outcomes; the most studied are FSTL1 (1 study), CTRP9 (1) and CTRP3 (1).

FSTL1

upin humans1

1 study
  1. High-intensity cycling increases FSTL1 in humans.

    “In the HIE trial, significant increases in the circulating concentrations of CTRP3, CTRP9, and FSTL1 were observed after exercise compared to before exercise”

    Human trialwhole-blood75% maximal oxygen uptakemalesn = 10

    Exercise intensity affects circulating C1q/TNF-related proteins and follistatin-like 1 concentrations

    Clinical physiology and functional imaging

More on FSTL1

CTRP9

upin humans1

1 study
  1. High-intensity cycling increases CTRP9 in humans.

    “In the HIE trial, significant increases in the circulating concentrations of CTRP3, CTRP9, and FSTL1 were observed after exercise compared to before exercise”

    Human trialwhole-blood75% maximal oxygen uptakemalesn = 10

    Exercise intensity affects circulating C1q/TNF-related proteins and follistatin-like 1 concentrations

    Clinical physiology and functional imaging

More on CTRP9

CTRP3

upin humans1

1 study
  1. High-intensity cycling increases CTRP3 in humans.

    “In the HIE trial, significant increases in the circulating concentrations of CTRP3, CTRP9, and FSTL1 were observed after exercise compared to before exercise”

    Human trialwhole-blood75% maximal oxygen uptakemalesn = 10

    Exercise intensity affects circulating C1q/TNF-related proteins and follistatin-like 1 concentrations

    Clinical physiology and functional imaging

More on CTRP3

Latest

Nov 2025: 1Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months