Herpes zoster vaccine
Intervention4 papers5 findings
- Humans1
- In silico1
Outcomes
1Mortality
downin silico1−56%Very low certainty
1 study
Mortality
downin silico1−56%Very low certainty
Herpes zoster vaccine decreases mortality in silico (56%).
In silicoimplied by published natural experiments
Natural experiments of herpes zoster vaccination: Quantifying the implied vaccine effectiveness against dementia · Brain, behavior, and immunity · 17 Sep 2026
Associations
2Dementia
downin humans2downin silico1Moderate certainty
3 studies
Dementia
downin humans2downin silico1Moderate certainty
Herpes zoster vaccine lowers the risk of dementia in humans.
Review
[The importance of varicella-zoster virus reactivation in adult central nervous system diseases] · Rinsho shinkeigaku = Clinical neurology · 19 Sep 2026
Herpes zoster vaccine lowers the risk of dementia in silico (18% (95% CI -0-35)).
In silicoimplied by published natural experiment in Wales
Natural experiments of herpes zoster vaccination: Quantifying the implied vaccine effectiveness against dementia · Brain, behavior, and immunity · 17 Sep 2026
Herpes zoster vaccine lowers the risk of dementia in humans (ratio estimate = 0.72; 95% CI: 0.65-0.81).
Reviewin observational studies
Association Between Herpes Zoster Vaccination and Dementia Risk: A Systematic Review and Meta-Analysis · Vaccines · 10 Aug 2026
Mild cognitive impairment
downin silico1−41%Very low certainty
1 study
Mild cognitive impairment
downin silico1−41%Very low certainty
Herpes zoster vaccine lowers the risk of mild cognitive impairment in silico (41%).
In silicoimplied by published natural experiments
Natural experiments of herpes zoster vaccination: Quantifying the implied vaccine effectiveness against dementia · Brain, behavior, and immunity · 17 Sep 2026