Hederagenin
Intervention1 paper3 findingsMeSH C025763
- Animals1
Outcomes
2Cellular senescence
downin human cells1downin mice1Very low certainty
1 study
Cellular senescence
downin human cells1downin mice1Very low certainty
Hederagenin decreases cellular senescence in human cells.
Cellsin palmitic acid-treated HK-2 cells
Hederagenin attenuates renal senescence in diabetic kidney disease by inhibiting DNMT1-mediated Klotho DNA methylation · Chinese journal of natural medicines · 21 Aug 2026
Hederagenin decreases cellular senescence in mice.
Animalsin db/db micekidney
Hederagenin attenuates renal senescence in diabetic kidney disease by inhibiting DNMT1-mediated Klotho DNA methylation · Chinese journal of natural medicines · 21 Aug 2026
KL
upin human cells1Very low certainty
1 study
KL
upin human cells1Very low certainty
Hederagenin increases KL in human cells.
Cellsin palmitic acid-treated HK-2 cells
Hederagenin attenuates renal senescence in diabetic kidney disease by inhibiting DNMT1-mediated Klotho DNA methylation · Chinese journal of natural medicines · 21 Aug 2026