Heat pulse
Intervention1 paper2 findings
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
- Cells1
Outcomes
2Circadian disruption
downin mice1
1 study
Circadian disruption
downin mice1
Heat pulse decreases circadian disruption in mice.
AnimalsIL-1α treatment; ex vivoArticular cartilage explant
Heat pulses resynchronise daily clocks in mouse cartilage · Osteoarthritis and cartilage · 8 Oct 2026
Circadian rhythm synchronisation
upin mice1
1 study
Circadian rhythm synchronisation
upin mice1
Heat pulse improves circadian rhythm synchronisation in mice.
AnimalsPER2::LUC reporter mice; ex vivoArticular cartilage explant43 °C60 min
Heat pulses resynchronise daily clocks in mouse cartilage · Osteoarthritis and cartilage · 8 Oct 2026
Latest
1Heat pulses resynchronise daily clocks in mouse cartilage
A 60-minute pulse at 43 °C resynchronised daily rhythms in cartilage explants from young and aged mice, counteracting disruption caused by an…A 60-minute pulse at 43 °C resynchronised daily rhythms in cartilage explants from young and aged mice, counteracting disruption caused by an inflammatory signal.