Heat inactivation

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Fonds de Recherche du Québec - Santé and 2 more

Model organisms1

Outcomes

Mitochondrial unfolded protein response

upin worms1

1 study

Heat inactivation activates mitochondrial unfolded protein response in worms.
“In contrast, heat‐inactivated bacteria elicited strong food avoidance, reduced pumping activity, activation of the mitochondrial unfolded protein response (UPRmt), decreased lipid stores and fertility, and increased survival relative to the other groups.”
Model organismsfed heat-inactivated E. coli OP50
Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan
Scientific reports23 Nov 2025

More on Mitochondrial unfolded protein response

Lifespan

upin worms1

1 study

Heat inactivation extends lifespan in worms.
“In contrast, heat‐inactivated bacteria elicited strong food avoidance, reduced pumping activity, activation of the mitochondrial unfolded protein response (UPRmt), decreased lipid stores and fertility, and increased survival relative to the other groups.”
Model organismsfed heat-inactivated E. coli OP50
Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan
Scientific reports23 Nov 2025

Fertility

downin worms1

1 study

Heat inactivation decreases fertility in worms.
“In contrast, heat‐inactivated bacteria elicited strong food avoidance, reduced pumping activity, activation of the mitochondrial unfolded protein response (UPRmt), decreased lipid stores and fertility, and increased survival relative to the other groups.”
Model organismsfed heat-inactivated E. coli OP50
Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan
Scientific reports23 Nov 2025

Pharyngeal pumping

downin worms1

1 study

Heat inactivation impairs pharyngeal pumping in worms.
“In contrast, heat‐inactivated bacteria elicited strong food avoidance, reduced pumping activity, activation of the mitochondrial unfolded protein response (UPRmt), decreased lipid stores and fertility, and increased survival relative to the other groups.”
Model organismsfed heat-inactivated E. coli OP50
Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan
Scientific reports23 Nov 2025

Latest

1 in 12 months

Scientific Reports24 Nov

Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan

Experiments in wormsInterventions

Paper

Heat inactivation

Outcomes

Latest

Impact of bacterial inactivation methods on Caenorhabditis elegans feeding and healthspan

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