GW9508

1. GW9508 inhibits MAPK/ERK signalling in mouse cells.

   “inhibiting the hyperactivation of the ERK1/2-MAPK pathway in senescent cells, ultimately enhancing the activity of aged iTECs.”

   Cellsin senescent cells

   GW9508-Induced Activation of GPR40 in Thymic Epithelial Cells: A Therapeutic Strategy to Delay Thymic Aging

   Aging cell·1 Jul 2026

More on MAPK/ERK signalling

1. GW9508 activates AMPK signalling in mouse cells.

   “GW9508 targeted GPR40 to elevate intracellular calcium ion levels, thereby activating the AMPK signaling pathway”

   Cellsin senescent cells

   GW9508-Induced Activation of GPR40 in Thymic Epithelial Cells: A Therapeutic Strategy to Delay Thymic Aging

   Aging cell·1 Jul 2026

More on AMPK signalling

1. GW9508 improves thymic function in mice.

   “demonstrated that GPR40 activation effectively restored thymic function in aged mice.”

   Animalsin aged mice

   GW9508-Induced Activation of GPR40 in Thymic Epithelial Cells: A Therapeutic Strategy to Delay Thymic Aging

   Aging cell·1 Jul 2026