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Guanidinoethyl sulfonate

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funder: National Natural Science Foundation of China
  • Cells1

Outcomes

3

SLC6A6

downin cells1

1 study

  1. Guanidinoethyl sulfonate inhibits SLC6A6 in cells.

    “both imidazole acetic acid and guanidinoethyl sulfonate (GES) inhibit TAUT by competing with taurine for the binding site”

    Cells

    Molecular basis for substrate recognition and transport of mammalian taurine transporters

    Proceedings of the National Academy of Sciences of the United States of America2 Jul 2025

More on SLC6A6

Cellular senescence

upin mouse cells1

1 study

  1. Guanidinoethyl sulfonate induces cellular senescence in mouse cells.

    “SLC6A6 inhibition delayed corneal wound healing, triggered senescence pathway activation”

    Cellscorneal epithelial stem/progenitor cells

    SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

    Investigative ophthalmology & visual science2 Jun 2025

More on Cellular senescence

Corneal wound healing

downin mice1

1 study

  1. Guanidinoethyl sulfonate impairs corneal wound healing in mice.

    “SLC6A6 inhibition delayed corneal wound healing”

    Animalsin corneal wound healing models

    SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

    Investigative ophthalmology & visual science2 Jun 2025

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