Glycine + n-acetylcysteine

1. Glycine + n-acetylcysteine improves physical function in humans.

   “Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks”

   Review

   JGMS EDITOR’S CHOICE ARTICLES OF 2023: RISK AND RECOVERY OF FUNCTIONAL DECLINE AND FRAILTY · GSA 2024 abstract · 31 Dec 2024

1. Glycine + n-acetylcysteine decreases inflammation in humans.

   “Supplementing GlyNAC for 24-weeks reversed these defects and improved cognition, but stopping GlyNAC for 12-weeks led to redevelopment of these defects.”

   Human trialin older adults24-weeks

   IMPROVING GLUTATHIONE, MITOCHONDRIA, INFLAMMATION, AND COGNITIVE DECLINE: A PILOT CLINICAL TRIAL OF GLYNAC IN AGING · GSA 2024 abstract · 31 Dec 2024

Inflammation →

1. Glycine + n-acetylcysteine decreases oxidative stress and ROS signalling in humans.

   “Supplementing GlyNAC for 24-weeks reversed these defects and improved cognition, but stopping GlyNAC for 12-weeks led to redevelopment of these defects.”

   Human trialin older adults24-weeks

   IMPROVING GLUTATHIONE, MITOCHONDRIA, INFLAMMATION, AND COGNITIVE DECLINE: A PILOT CLINICAL TRIAL OF GLYNAC IN AGING · GSA 2024 abstract · 31 Dec 2024

Oxidative stress and ROS signalling →

1. Glycine + n-acetylcysteine improves cognitive function in humans.

   “Supplementing GlyNAC for 24-weeks reversed these defects and improved cognition”

   Human trialin older adults24-weeks

   IMPROVING GLUTATHIONE, MITOCHONDRIA, INFLAMMATION, AND COGNITIVE DECLINE: A PILOT CLINICAL TRIAL OF GLYNAC IN AGING · GSA 2024 abstract · 31 Dec 2024