Ganglioside GD1A

1. Ganglioside GD1A increases femur bone volume in mice.

   “As a result, femur bone volume in ganglioside GD1a-treated LmnaDhe/+ mice was more significantly increased than in the LmnaDhe/+ mice.”

   Animalsin congenital progeria LmnaDhe/+ micefemur

   Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of Lmna mutant mice

   Aging·Nov 14, 2022

1. Ganglioside GD1A activates MAPK/ERK signaling in mouse cells.

   “In addition, the level of pERK1/2, related to bone differentiation mechanisms was significantly increased.”

   Cellsin Lmna-mutated MSCs3 μg/ml

   Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of Lmna mutant mice

   Aging·Nov 14, 2022

More on MAPK/ERK signaling

1. Ganglioside GD1A increases stem cell differentiation in mouse cells.

   “A result of treating MSCs with Lmna dysfunction with ganglioside GD1a (3 μg/ml), significantly increased bone differentiation in ganglioside GD1a treatment to Lmna-mutated MSCs.”

   Cellsin Lmna-mutated MSCs3 μg/ml

   Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of Lmna mutant mice

   Aging·Nov 14, 2022

More on Stem cell differentiation