G-1
Intervention1 paper3 findingsPubChem 5322399ChEBI 156296
- Animals1
Outcomes
3Mitophagy
upin mice1Very low certainty
1 study
Mitophagy
upin mice1Very low certainty
G-1 activates mitophagy in mice.
Animalsin OVX mice with HFpEF4 weeksfemales
GPER stimulation attenuates mitochondrial dysfunction and cardiac dysfunction in ovariectomized mice with heart failure with preserved ejection fraction (HFpEF) · British journal of pharmacology · 10 Sep 2026
Myocardial hypertrophy
downin mice1Very low certainty
1 study
Myocardial hypertrophy
downin mice1Very low certainty
G-1 decreases myocardial hypertrophy in mice.
Animalsin OVX mice with HFpEF4 weeksfemales
GPER stimulation attenuates mitochondrial dysfunction and cardiac dysfunction in ovariectomized mice with heart failure with preserved ejection fraction (HFpEF) · British journal of pharmacology · 10 Sep 2026
Diastolic function
upin mice1Very low certainty
1 study
Diastolic function
upin mice1Very low certainty
G-1 improves diastolic function in mice.
Animalsin OVX mice with HFpEF4 weeksfemales
GPER stimulation attenuates mitochondrial dysfunction and cardiac dysfunction in ovariectomized mice with heart failure with preserved ejection fraction (HFpEF) · British journal of pharmacology · 10 Sep 2026