Frizzled 5 receptor agonist
Intervention1 paper3 findings
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
3 of 3 findings with company ties
- Animals1
Outcomes
3Pulmonary fibrosis
no changein mice1
1 study
Pulmonary fibrosis
no changein mice1
Frizzled 5 receptor agonist has no effect on pulmonary fibrosis in mice.
Animalsfollowing injury in aged miceengineered agonistlung
Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair · bioRxiv · 21 Aug 2026 · Preprint
Tissue damage
downin mice1
1 study
Tissue damage
downin mice1
Frizzled 5 receptor agonist decreases tissue damage in mice.
Animalsupon acute lung injuryengineered agonistlung
Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair · bioRxiv · 21 Aug 2026 · Preprint
Type II pneumocyte
upin mice1
1 study
Type II pneumocyte
upin mice1
Frizzled 5 receptor agonist increases type II pneumocyte in mice.
Animalschronic treatment in aged miceengineered agonistlung
Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair · bioRxiv · 21 Aug 2026 · Preprint