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Folfiri

Intervention

3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Natural Sciences and Engineering Research Council of Canada and 1 more

Outcomes

3

BCKDHA

upin mice1

1 study

  1. Folfiri activates BCKDHA in mice.

    “In response to chemotherapy, gastrocnemius muscle of males but not females had reduced inhibitory phosphorylation of BCKD-E1αser293, corresponding with increased activity of this enzyme.”

    Animalsgastrocnemius muscle6 weeksmales

    Sex differences in cachexia outcomes and branched-chain amino acid metabolism following chemotherapy in aged mice

    PloS one12 Jan 2026

More on BCKDHA

Skeletal muscle weight

downin mice1

1 study

  1. Folfiri decreases skeletal muscle weight in mice.

    “In response to chemotherapy, males showed worsened outcomes for skeletal muscle weight and ubiquitinated proteins”

    Animalsskeletal muscle6 weeks

    Sex differences in cachexia outcomes and branched-chain amino acid metabolism following chemotherapy in aged mice

    PloS one12 Jan 2026

Body weight

downin mice1

1 study

  1. Folfiri decreases body weight in mice.

    “There was a main effect of chemotherapy, reflected in reduced body weight, skeletal muscle, myofibrillar protein content, anabolic signalling and protein synthesis.”

    Animals6 weeks

    Sex differences in cachexia outcomes and branched-chain amino acid metabolism following chemotherapy in aged mice

    PloS one12 Jan 2026

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