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Folate-deficient diet

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of General Medical Sciences and 1 more
  • Animals1

Outcomes

2

Lifespan

upin mice1

1 study

  1. Folate-deficient diet extends lifespan in mice (almost threefold).

    “results in an almost threefold extension of mean life span in the protein repair-deficient mice”

    Animalsin PCMT1-deficient mice

    Diet-dependent survival of protein repair-deficient mice

    The Journal of nutritional biochemistry1 Sep 2005

S-adenosylmethionine to S-adenosylhomocysteine ratio

downin mice1

1 study

  1. Folate-deficient diet decreases S-adenosylmethionine to S-adenosylhomocysteine ratio in mice.

    “the low-folate diet significantly decreases the AdoMet/AdoHcy ratio in brain tissue”

    Animalsin PCMT1-deficient micebrain

    Diet-dependent survival of protein repair-deficient mice

    The Journal of nutritional biochemistry1 Sep 2005

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