Fimepinostat

1. Fimepinostat increases TP53 in cells.

   “leads to an increase in p53 and a reduction in BH3 pro-survival proteins”

   Cellsin senescent cells

   Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic

   Aging·Mar 28, 2023

More on TP53

1. Fimepinostat decreases cellular senescence in cells.

   “CUDC-907 showed senolytic properties in different models of stress-induced senescence”

   Cellsin different models of stress-induced senescence

   Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic

   Aging·Mar 28, 2023

More on Cellular senescence

1. Fimepinostat induces apoptosis in cells.

   “CUDC-907 was indeed able to selectively induce apoptosis in cells driven to senesce by p53 expression”

   Cellsin cells driven to senesce by p53 expression

   Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic

   Aging·Mar 28, 2023

More on Apoptosis